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Recurrent Pregnancy Loss Clinic

Increasing pregnancy rates after
complete analysis of exact reason
of recurrent pregnancy loss

For inquires:
031-782-8300(KOR) / +82-10-8866-2268(ENG)
Patients who’ve had more than three IVF procedures but was continuously unsuccessful or resulted in chemical pregnancy, despite transferring high quality embryos, are classified as repeated implantation failure (RIF). In cases of such repeated implantation failure, various tests should be done to determine the cause, as they represent characteristics of habitual abortion.
Causes and Exams
  1. 1 Abnormal shape of the uterus   Hysterosalpingography, ultrasound, hysteroscopy
  2. 2 Abnormal anatomy of the uterus   Hysterosalpingography, ultrasound, hysteroscopy
  3. 3 Chromosomal abnormality   Parental karyotype testing to detect chromosome abnormalities
  4. 4 Bacterial infection   Evaluation of bacterial infections such as vaginitis and salpingitis
  5. 5 Endocrine abnormality   Tests for decline in ovarian function, obesity, diabetes and thyroid hormone and prolactin, etc.
  6. 6 Autoimmune diseases   Natural killer (NK) cell and various autoimmune antibody test
  7. 7 Disorders of Coagulation / Thrombophilia   Gene mutation tests related to C protein, S protein, antithrombin III, and MTHFR gene C677T formation tests for blood circulation disorders in the placenta (Factor V Leiden, Prothrombin, Homocysteine)
  8. 8 Uterine Anomalies
  9. 9 Male infertility
  10. 10 Medical questionnaire   Daily lifestyle, working environment/conditions, medication use, etc.
Causes and Treatments
Type Cause Treatment
  1. 11. Anatomical factor of uterus
Check for abnormalities through hysteroscopy
  1. 2Thin endometrium
Endometrial stimulation and biopsy, various medications (Viagra, high-dose estrogen, etc.)
  1. 3Immunological factors
Immunoglobulin, steroid, heparin, aspirin administration
  1. 4Thrombosis
Blood tests to check for any blood circulation disorders in the placenta
Poor embryo quality Genetic abnormality :
genetic screening test before implantation
Check for chromosomal abnormalities
hardening egg coat Assisted incubation or blastocyst embryos
Other hardening egg coat Use of gonadotropin-releasing hormone agents
Hydrosalpinx Resection of the fallopian tube by performing laparoscopic surgery
Implantation and
Uterine Lining
In the case of permanent damage to the base membrane of the endometrium due to uterine surgery or endometritis, a decrease in blood circulation to the base membrane of the endometrium after uterine myoma or endometrial surgery, an endometrial that is not responsive to female hormone administration, an inappropriate response to ovulation hyperstimulation injections, or excessive release of male hormones from ovaries, decreases the chances of implantation in the uterine wall.
Because the causes of repeated implantation failures are diverse and complicated, it is necessary to find the cause through sufficient consultation, observation, and examination with an experienced fertility specialist to ensure that the implantation is successful